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J Occup Health. 2011;53(6):417-22. Epub 2011 Oct 13.

Exposure to respirable flour dust and gliadin in wheat flour mills.

Author information

1
Department of Biochemistry and Nutrition, Hamadan University of Medical Sciences. khodadadi@umsha.ac.ir

Abstract

OBJECTIVES:

The aim of this study was to determine the concentrations of respirable flour dusts and gliadin as well as gliadin-specific serum antibodies in exposed workers of Hamadan wheat flour mill factories.

METHODS:

Blood samples from 95 exposed workers and 80 air samples from flour packing, husk packing, flour production and wheat unloading areas were collected. Respirable flour dust density was measured by a gravimetric method, and dust gliadin concentration as well as serum antibodies were determined by enzyme-linked immunosorbent assays.

RESULTS:

The Time-weighted average (TWA) flour dust density was higher in all factories (1.56-4.68 mg/m(3)) compared with the threshold limit value (0.5 mg/m(3)) of ACGIH and showed a positive correlation with the gliadin concentration (p<0.05). Additionally, the respirable dust and gliadin concentrations were significantly higher at flour packing workstations compare with the other work areas. Moreover, the mean serum gliadin-specific IgA and IgG and total IgE antibodies were remarkably higher in exposed mill workers compared with the controls (p<0.05).

CONCLUSION:

We clearly demonstrated that workers in Hamadan flour mills are in exposed to a hazardous level of respirable flour dust, receiving the highest level of dust and gliadin in flour packing areas. Furthermore, dust-exposed workers showed upper levels of serum antibodies indicating exposure to higher amounts of allergens than controls.

PMID:
21996928
DOI:
10.1539/joh.11-0045-oa
[Indexed for MEDLINE]
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