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Trends Immunol. 2011 Dec;32(12):582-8. doi: 10.1016/j.it.2011.09.003. Epub 2011 Oct 11.

Type I interferon response to extracellular bacteria in the airway epithelium.

Author information

1
Department of Pediatrics, Columbia University, New York, NY, USA.

Abstract

The airway epithelium possesses many mechanisms to prevent bacterial infection. Not only does it provide a physical barrier, but it also acts as an extension of the immune system through the expression of innate immune receptors and corresponding effectors. One outcome of innate signaling by the epithelium is the production of type I interferons (IFNs), which have traditionally been associated with activation via viral and intracellular organisms. We discuss how three extracellular bacterial pathogens of the airway activate this intracellular signaling cascade through both surface components as well as via secretion systems, and the differing effects of type I IFN signaling on host defense of the respiratory tract.

PMID:
21996313
PMCID:
PMC3221817
DOI:
10.1016/j.it.2011.09.003
[Indexed for MEDLINE]
Free PMC Article

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