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Viruses. 2011 Aug;3(8):1342-57. doi: 10.3390/v3081342. Epub 2011 Aug 4.

Impact of the autophagy machinery on hepatitis C virus infection.

Author information

1
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. marlene.dreux@ens-lyon.fr

Abstract

Autophagy is a cellular process that catabolizes cytoplasmic components and maintains energy homeostasis. As a stress response, the autophagy machinery interconnects a wide range of cellular pathways, enhancing the spread of certain pathogens while limiting others, and has become a highly active research area over the past several years. Independent laboratories have recently reported that autophagy vesicles accumulate in hepatitis C virus (HCV) infected cells and that autophagy proteins can function as proviral factors required for HCV replication. In this review, we summarize what is currently known about the interplay between autophagy and HCV and the possible mechanisms whereby autophagy proteins might favor HCV propagation.

KEYWORDS:

ER-stress response; HCV; RIG-I; autolysosome; autophagic vesicle; autophagy; hepatitis C virus; innate host response; interferon; unfolded protein response

PMID:
21994783
PMCID:
PMC3185811
DOI:
10.3390/v3081342
[Indexed for MEDLINE]
Free PMC Article

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