Format

Send to

Choose Destination
See comment in PubMed Commons below
Viruses. 2011 Jul;3(7):1281-311. doi: 10.3390/v3071281. Epub 2011 Jul 21.

Viruses, autophagy genes, and Crohn's disease.

Author information

1
Skirball Institute of Biomolecular Medicine, Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA.

Abstract

The etiology of the intestinal disease Crohn's disease involves genetic factors as well as ill-defined environmental agents. Several genetic variants linked to this disease are associated with autophagy, a process that is critical for proper responses to viral infections. While a role for viruses in this disease remains speculative, accumulating evidence indicate that this possibility requires serious consideration. In this review, we will examine the three-way relationship between viruses, autophagy genes, and Crohn's disease and discuss how host-pathogen interactions can mediate complex inflammatory disorders.

KEYWORDS:

ATG16L1; Crohn’s disease; MNV; Paneth cells; autophagy; inflammatory bowel disease; intestine; mucosal immunity; norovirus

PMID:
21994779
PMCID:
PMC3185787
DOI:
10.3390/v3071281
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
    Loading ...
    Support Center