Format

Send to

Choose Destination
Viruses. 2011 Jun;3(6):906-19. doi: 10.3390/v3060906. Epub 2011 Jun 23.

RIG-I like receptors in antiviral immunity and therapeutic applications.

Author information

1
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA. rireton@u.washington.edu

Abstract

The RNA helicase family of RIG-I-like receptors (RLRs) is a key component of host defense mechanisms responsible for detecting viruses and triggering innate immune signaling cascades to control viral replication and dissemination. As cytoplasm-based sensors, RLRs recognize foreign RNA in the cell and activate a cascade of antiviral responses including the induction of type I interferons, inflammasome activation, and expression of proinflammatory cytokines and chemokines. This review provides a brief overview of RLR function, ligand interactions, and downstream signaling events with an expanded discussion on the therapeutic potential of targeting RLRs for immune stimulation and treatment of virus infection.

KEYWORDS:

RIG-I; adjuvant; inflammation

PMID:
21994761
PMCID:
PMC3185779
DOI:
10.3390/v3060906
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center