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Viruses. 2011 May;3(5):520-40. doi: 10.3390/v3050520. Epub 2011 May 6.

Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction.

Author information

1
Department of Infectious Disease, King's College London School of Medicine, Guy's Hospital, London SE19RT, UK.

Abstract

Tetherin (BST2/CD317) has been recently recognized as a potent interferon-induced antiviral molecule that inhibits the release of diverse mammalian enveloped virus particles from infected cells. By targeting an immutable structure common to all these viruses, the virion membrane, evasion of this antiviral mechanism has necessitated the development of specific countermeasures that directly inhibit tetherin activity. Here we review our current understanding of the molecular basis of tetherin's mode of action, the viral countermeasures that antagonize it, and how virus/tetherin interactions may affect viral transmission and pathogenicity.

KEYWORDS:

Tetherin/BST2; Vpu; interferon; restriction of enveloped virus release; viral countermeasure

PMID:
21994744
PMCID:
PMC3185764
DOI:
10.3390/v3050520
[Indexed for MEDLINE]
Free PMC Article

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