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Viruses. 2011 Mar;3(3):172-203. doi: 10.3390/v3030172. Epub 2011 Feb 25.

Bacteriophage assembly.

Author information

1
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA. aaksyuk@purdue.edu

Abstract

Bacteriophages have been a model system to study assembly processes for over half a century. Formation of infectious phage particles involves specific protein-protein and protein-nucleic acid interactions, as well as large conformational changes of assembly precursors. The sequence and molecular mechanisms of phage assembly have been elucidated by a variety of methods. Differences and similarities of assembly processes in several different groups of bacteriophages are discussed in this review. The general principles of phage assembly are applicable to many macromolecular complexes.

KEYWORDS:

assembly; bacteriophage; genome packaging; macromolecular complex; maturation

PMID:
21994726
PMCID:
PMC3185693
DOI:
10.3390/v3030172
[Indexed for MEDLINE]
Free PMC Article

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