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Genetics. 2011 Oct;189(2):405-9. doi: 10.1534/genetics.111.134197.

Solving a meiotic LEGO puzzle: transverse filaments and the assembly of the synaptonemal complex in Caenorhabditis elegans.

Author information

1
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA. rsh@stowers.org

Abstract

The structure of the meiosis-specific synaptonemal complex, which is perhaps the central visible characteristic of meiotic prophase, has been a matter of intense interest for decades. Although a general picture of the interactions between the transverse filament proteins that create this structure has emerged from studies in a variety of organisms, a recent analysis of synaptonemal complex structure in Caenorhabditis elegans by Schild-Prüfert et al. (2011) has provided the clearest picture of the structure of the architecture of a synaptonemal complex to date. Although the transverse filaments of the worm synaptonemal complex are assembled differently then those observed in yeast, mammalian, and Drosophila synaptonemal complexes, a comparison of the four assemblies shows that achieving the overall basic structure of the synaptonemal complex is far more crucial than conserving the structures of the individual transverse filaments.

PMID:
21994217
PMCID:
PMC3189802
DOI:
10.1534/genetics.111.134197
[Indexed for MEDLINE]
Free PMC Article

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