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Laryngoscope. 2011 Nov;121(11):2468-72. doi: 10.1002/lary.22176. Epub 2011 Oct 12.

Xylitol nasal irrigation in the management of chronic rhinosinusitis: a pilot study.

Author information

1
Department of Otolaryngology-Head and Neck Surgery, Stanford Hospital and Clinics, Stanford, California, USA.

Erratum in

  • Laryngoscope. 2012 Nov;122(11):2611.

Abstract

OBJECTIVES/HYPOTHESIS:

To determine the tolerability of xylitol mixed with water as a nasal irrigant and to evaluate whether xylitol nasal irrigation results in symptomatic improvement of subjects with chronic rhinosinusitis.

STUDY DESIGN:

A prospective, randomized, double-blinded, controlled crossover pilot study.

METHODS:

Twenty subjects were instructed to perform sequential 10-day courses of daily xylitol and saline irrigations in a randomized fashion, with a 3-day washout irrigation rest period at the start of each treatment arm. Collected data included patient characteristics, along with Sino-Nasal Outcome Test 20 (SNOT-20) and Visual Analog Scale (VAS) scores reported at the beginning and end of each irrigation course.

RESULTS:

Fifteen of the 20 subjects (75%) returned their SNOT-20 and VAS data for analysis. There was a significant reduction in SNOT-20 score during the xylitol phase of irrigation (mean drop of 2.43 points) as compared to the saline phase (mean increase of 3.93 points), indicating improved sinonasal symptoms (P = .0437). There was no difference in VAS scores. No patient stopped performing the irrigations owing to intolerance of the xylitol, although its sweet taste was not preferred by three subjects (21%). One patient reported transient stinging with xylitol.

CONCLUSIONS:

Xylitol in water is a well-tolerated agent for sinonasal irrigation. In the short term, xylitol irrigations result in greater improvement of symptoms of chronic rhinosinusitis as compared to saline irrigation.

PMID:
21994147
DOI:
10.1002/lary.22176
[Indexed for MEDLINE]

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