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Nat Rev Cancer. 2011 Oct 13;11(11):761-74. doi: 10.1038/nrc3106.

RAS oncogenes: weaving a tumorigenic web.

Author information

1
Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA.

Abstract

RAS proteins are essential components of signalling pathways that emanate from cell surface receptors. Oncogenic activation of these proteins owing to missense mutations is frequently detected in several types of cancer. A wealth of biochemical and genetic studies indicates that RAS proteins control a complex molecular circuitry that consists of a wide array of interconnecting pathways. In this Review, we describe how RAS oncogenes exploit their extensive signalling reach to affect multiple cellular processes that drive tumorigenesis.

PMID:
21993244
PMCID:
PMC3632399
DOI:
10.1038/nrc3106
[Indexed for MEDLINE]
Free PMC Article

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