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J Infect Dis. 2011 Nov;204 Suppl 3:S953-6. doi: 10.1093/infdis/jir325.

The Ebolavirus VP24 protein blocks phosphorylation of p38 mitogen-activated protein kinase.

Author information

1
Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin-Madison, WI, USA.

Abstract

Type I interferon (IFN) signaling is mediated through several signaling pathways, including the Janus kinase and signal transducer and activator (JAK-STAT) and p38 mitogen-activated protein (MAP) kinase pathways. The VP24 protein of Ebolavirus is an IFN antagonist, blocking type I IFN signaling through the JAK-STAT pathway. Here, we show that, in 293 cells, VP24 also interferes with the p38 MAP kinase pathway by blocking IFN-β-stimulated phosphorylation of p38-α. Similar inhibition was not observed in HeLa cells, suggesting cell type-specific differences in signal transduction.

PMID:
21987775
PMCID:
PMC3189987
DOI:
10.1093/infdis/jir325
[Indexed for MEDLINE]
Free PMC Article

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