Format

Send to

Choose Destination
Arch Neurol. 2012 Feb;69(2):257-61. doi: 10.1001/archneurol.2011.1002. Epub 2011 Oct 10.

Identifying subtle cortical gyral abnormalities as a predictor of focal cortical dysplasia and a cure for epilepsy.

Author information

1
Tufts University and Lahey Clinic, 41 Mall Rd, Burlington, MA 01805, USA. joel.m.oster@lahey.org

Abstract

OBJECTIVES:

To highlight a case series of 3 cases of focal cortical dysplasia that were unrecognized for many years though the patients were seen by various neurologists and received the appropriate neuroimaging studies, and to retrospectively characterize the clinical elements, neuroimaging, electroencephalography, and pathologic findings in these cases.

DESIGN:

Retrospective descriptive study.

SETTING:

Tertiary urban and suburban neurology and epilepsy outpatient and inpatient clinic settings and hospitals.

PATIENTS:

We analyze retrospectively 3 patients in whom magnetic resonance images were previously deemed as normal, who, in fact, exhibited subtle gyral abnormalities and who underwent focal surgical resections of these regions after invasive electroencephalography monitoring or electrocorticography and were cured of their epilepsy.

MAIN OUTCOME MEASURES:

Clinical semiology and neuroimaging findings.

RESULTS:

Focal cortical dysplasias may present with subtle gyral abnormalities. These gyral abnormalities may guide invasive electroencephalography or electrocorticography and may delineate seizure onsets with precision. Resection of these areas in 3 such patients resulted in excellent surgical outcomes.

CONCLUSIONS:

Subtle gyral abnormalities may be associated with intractable epilepsy and seizure onsets. Focal resection after appropriate evaluations in selected patients may be curative. The magnetic resonance imaging features of focal cortical dysplasia can be subtle and require a high index of suspicion based on ictal semiology and clinical presentation.

PMID:
21987396
DOI:
10.1001/archneurol.2011.1002
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center