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Antimicrob Agents Chemother. 2012 Jan;56(1):591-4. doi: 10.1128/AAC.05352-11. Epub 2011 Oct 10.

ICESp2905, the erm(TR)-tet(O) element of Streptococcus pyogenes, is formed by two independent integrative and conjugative elements.

Author information

1
Department of Biomedical Sciences, Section of Microbiology, Marche Polytechnic University, Ancona, Italy.

Abstract

In ICESp2905, a widespread erm(TR)- and tet(O)-carrying genetic element of Streptococcus pyogenes, the two resistance determinants are contained in separate fragments inserted into a scaffold of clostridial origin. ICESp2905 (∼65.6 kb) was transferable not only in its regular form but also in a defective form lacking the erm(TR) fragment (ICESp2906, ∼53.0 kb). The erm(TR) fragment was also an independent integrative and conjugative element (ICE) (ICESp2907, ∼12.6 kb). ICESp2905 thus results from one ICE (ICESp2907) being integrated into another (ICESp2906).

PMID:
21986826
PMCID:
PMC3256084
DOI:
10.1128/AAC.05352-11
[Indexed for MEDLINE]
Free PMC Article

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