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Clin Biochem. 2011 Dec;44(17-18):1440-4. doi: 10.1016/j.clinbiochem.2011.09.012. Epub 2011 Oct 2.

Reference intervals for saliva analytes collected by a standardized method in a physically active population.

Author information

1
Laboratory of Exercise Biochemistry - LABEX, Biochemistry Department, Biology Institute, State University of Campinas, Cidade Universitária Zeferino Vaz, s/n, Barão Geraldo, CEP: 13083-970, CP6109, Campinas, SP, Brazil. lazaroalessandro@yahoo.com.br

Abstract

OBJECTIVES:

Our aims were to test a liquid-based saliva collection system for total antioxidant status (TAS), uric acid (UA), total protein concentration (TP) and salivary alpha-amylase (SAA) activity; to determine if these analytes in serum and saliva are correlated in a physically active population and to establish reference intervals for these parameters.

DESIGN AND METHODS:

Participants in this study were 115 physically active males (18-20 years old). Saliva samples were collected using the Saliva Collection System (Greiner Bio-One) immediately before obtaining blood. Biochemical analyses were conducted using an Autolab Boehringer analyzer.

RESULTS:

We found a correlation between UA and TP concentrations in serum and saliva samples. The reference intervals for TP and SAA activity in the morning were lower than in the afternoon (p<0.0001). The reference intervals for UA and TAS did not vary with the time of collection.

CONCLUSION:

The establishment of reference intervals for these saliva constituents increases their diagnostic utility and allows for detection of physiological or pathological states.

[Indexed for MEDLINE]

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