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Bioorg Med Chem Lett. 2011 Nov 15;21(22):6641-5. doi: 10.1016/j.bmcl.2011.09.069. Epub 2011 Sep 22.

A modular approach to trim cellular targets in anticancer drug discovery.

Author information

1
BioLab, Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, C/ Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.

Abstract

A Phenotypic Drug Discovery strategy was applied to study a set of pyrimidine analogs prepared by means of intramolecular oxidation-reduction reactions of N-substituted-N-(2,6-disubstituted-5-nitro-4-pyrimidinyl)aminoacetic acid methyl esters in basic media. The combined and rational use of specific assays allowed in short time reducing from all possible cellular targets to those involved in metaphase to anaphase transition.

PMID:
21986585
DOI:
10.1016/j.bmcl.2011.09.069
[Indexed for MEDLINE]

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