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PLoS One. 2011;6(10):e24431. doi: 10.1371/journal.pone.0024431. Epub 2011 Oct 3.

A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense.

Author information

1
Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. h.veninga@vumc.nl

Abstract

BACKGROUND:

In addition to its complement-regulating activity, CD55 is a ligand of the adhesion class G protein-coupled receptor CD97; however, the relevance of this interaction has remained elusive. We previously showed that mice lacking a functional CD97 gene have increased numbers of granulocytes.

METHODOLOGY/RESULTS:

Here, we demonstrate that CD55-deficient mice display a comparable phenotype with about two-fold more circulating granulocytes in the blood stream, the marginated pool, and the spleen. This granulocytosis was independent of increased complement activity. Augmented numbers of Gr-1-positive cells in cell cycle in the bone marrow indicated a higher granulopoietic activity in mice lacking either CD55 or CD97. Concomitant with the increase in blood granulocyte numbers, Cd55⁻/⁻ mice challenged with the respiratory pathogen Streptococcus pneumoniae developed less bacteremia and died later after infection.

CONCLUSIONS:

Collectively, these data suggest that complement-independent interaction of CD55 with CD97 is functionally relevant and involved in granulocyte homeostasis and host defense.

PMID:
21984892
PMCID:
PMC3184942
DOI:
10.1371/journal.pone.0024431
[Indexed for MEDLINE]
Free PMC Article

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