Format

Send to

Choose Destination
Cell Mol Life Sci. 2012 Feb;69(4):535-52. doi: 10.1007/s00018-011-0814-3. Epub 2011 Oct 8.

Control of cytoplasmic mRNA localization.

Author information

1
Department of Biochemistry, Université de Montréal, 2900 Edouard-Montpetit, Montréal, Qc, Canada.

Abstract

mRNA localization is a mechanism used by various organisms to control the spatial and temporal production of proteins. This process is a highly regulated event that requires multiple cis- and trans-acting elements that mediate the accurate localization of target mRNAs. The intrinsic nature of localization elements, together with their interaction with different RNA-binding proteins, establishes control mechanisms that can oversee the transcript from its birth in the nucleus to its specific final destination. In this review, we aim to summarize the different mechanisms of mRNA localization, with a particular focus on the various control mechanisms that affect the localization of mRNAs in the cytoplasm.

PMID:
21984598
DOI:
10.1007/s00018-011-0814-3
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center