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[Anti-proliferation and chemo-sensitization effects of apigenin on human lung cancer cells].

[Article in Chinese]

Author information

1
Department of Biochemistry and Genetics, Zhejiang University School of Medicine, Hangzhou, China.

Abstract

OBJECTIVE:

To investigate the antitumor effect of apigenin on human lung cancer cells.

METHODS:

The anti-proliferation and sensitization effects of apigenin on human lung cancer cells was accessed by counting cells after Trypan blue staining and MTS assay.

RESULTS:

(1) Apigenin significantly suppressed the proliferation of four types of human lung cancer cells (A549:P=0.041, H460:P=0.050, LTEP-a2:P=0.039, H292:P=0.016); (2) Apigenin significantly increased the susceptibility of human lung cancer cells to antitumor drugs (P<0.05 or P<0.01) in a synergistic way (almost all of the combination index values are less than 1).

CONCLUSION:

Apigenin widely inhibits cell proliferation of various lung cancer cell lines in a dose-dependent manner and the combination treatment of apigenin and antitumor drugs is very effective in human lung cancer cells, and Nrf2-ARE pathway may contribute to the mechanism.

PMID:
21984153
[Indexed for MEDLINE]

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