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Mol Imaging Biol. 2012 Aug;14(4):408-19. doi: 10.1007/s11307-011-0519-x.

Mouse atlas registration with non-tomographic imaging modalities-a pilot study based on simulation.

Author information

1
Crump Institute of Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. wang.hongkai@gmail.com

Abstract

PURPOSE:

This study investigates methodologies for the estimation of small animal anatomy from non-tomographic modalities, such as planar X-ray projections, optical cameras, and surface scanners. The key goal is to register a digital mouse atlas to a combination of non-tomographic modalities, in order to provide organ-level anatomical references of small animals in 3D.

PROCEDURES:

A 2D/3D registration method was developed to register the 3D atlas to the combination of non-tomographic imaging modalities. Eleven combinations of three non-tomographic imaging modalities were simulated, and the registration accuracy of each combination was evaluated.

RESULTS:

Comparing the 11 combinations, the top-view X-ray projection combined with the side-view optical camera yielded the best overall registration accuracy of all organs. The use of a surface scanner improved the registration accuracy of skin, spleen, and kidneys.

CONCLUSIONS:

The methodologies and evaluation presented in this study should provide helpful information for designing preclinical atlas-based anatomical data acquisition systems.

PMID:
21983855
PMCID:
PMC3340486
DOI:
10.1007/s11307-011-0519-x
[Indexed for MEDLINE]
Free PMC Article

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