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Nat Immunol. 2011 Oct 9;12(11):1071-7. doi: 10.1038/ni.2133.

An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation.

Author information

1
Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, Mill Hill, UK.

Abstract

Interleukin 9 (IL-9) is a cytokine linked to lung inflammation, but its cellular origin and function remain unclear. Here we describe a reporter mouse strain designed to map the fate of cells that have activated IL-9. We found that during papain-induced lung inflammation, IL-9 production was largely restricted to innate lymphoid cells (ILCs). IL-9 production by ILCs depended on IL-2 from adaptive immune cells and was rapidly lost in favor of other cytokines, such as IL-13 and IL-5. Blockade of IL-9 production via neutralizing antibodies resulted in much lower expression of IL-13 and IL-5, which suggested that ILCs provide the missing link between the well-established functions of IL-9 in the regulation of type 2 helper T cell cytokines and responses.

PMID:
21983833
PMCID:
PMC3198843
DOI:
10.1038/ni.2133
[Indexed for MEDLINE]
Free PMC Article

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