Format

Send to

Choose Destination
See comment in PubMed Commons below
Semin Cell Dev Biol. 2011 Oct;22(8):858-64. doi: 10.1016/j.semcdb.2011.09.013. Epub 2011 Oct 1.

Translating cell polarity into tissue elongation.

Author information

1
Howard Hughes Medical Institute, Developmental Biology Program, Sloan-Kettering Institute, New York, NY 10065, USA.

Abstract

Planar cell polarity, the orientation of single-cell asymmetries within the plane of a multicellular tissue, is essential to generating the shape and dimensions of organs and organisms. Planar polarity systems align cell behavior with the body axes and orient the cellular processes that lead to tissue elongation. Using Drosophila as a model system, significant progress has been made toward understanding how planar polarity is generated by biochemical and mechanical signals. Recent studies using time-lapse imaging reveal that cells engage in a number of active behaviors whose orientation and dynamics translate planar cell polarity into tissue elongation. Here we review recent progress in understanding the cellular mechanisms that link planar polarity to large-scale changes in tissue structure.

PMID:
21983030
PMCID:
PMC4752253
DOI:
10.1016/j.semcdb.2011.09.013
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center