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Bioorg Med Chem. 2011 Nov 15;19(22):6873-80. doi: 10.1016/j.bmc.2011.09.028. Epub 2011 Sep 21.

9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp.

Author information

1
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, PR China.

Abstract

Fourteen new 9,10-secosteroids designated as astrogorgols A-N (1-14) were isolated from a Chinese gorgonian Astrogorgia sp. together with eight known analogues. The structural patterns were characterized by the presence of a sterol-based 9,10-seco nucleus containing a 3-hydroxy-10-methylphenyl ring. Astrogorgol N (14) possessing a 1,4-dien-3-one unit in ring A was biogenetically considered as an intermediate to generate diverse 9,10-secosteroids. Five compounds showed significant inhibitory activities against human tumor related protein kinases, including ALK, AXL, FAK, IGF-1R, MET wt, SRC, and VEGF-R2.

PMID:
21982797
DOI:
10.1016/j.bmc.2011.09.028
[Indexed for MEDLINE]

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