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Immunity. 2011 Oct 28;35(4):611-21. doi: 10.1016/j.immuni.2011.09.010. Epub 2011 Oct 6.

Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E.

Author information

1
Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054-1901, USA.

Abstract

Although several interleukin-17 (IL-17) family members and their receptors have been recently appreciated as important regulators in inflammatory diseases, the function of other IL-17 cytokines and IL-17 receptor-like molecules is unclear. Here we show that an IL-17 cytokine family member, IL-17C, was induced in a Th17 cell-dependent autoimmune disease and was required for its pathogenesis. IL-17C bound to IL-17RE, a member of IL-17 receptor family whose full-length isoform was selectively expressed in Th17 cells and signaled via an IL-17RA-RE receptor complex and the downstream adaptor Act1. IL-17C-IL-17RE induced the expression of a nuclear IkappaB family member, IκBζ, in Th17 cells to potentiate the Th17 cell response. Thus, our work has identified a cytokine-receptor pair with important function in regulating proinflammatory responses. This pathway may be targeted to treat autoimmune diseases.

PMID:
21982598
PMCID:
PMC5800502
DOI:
10.1016/j.immuni.2011.09.010
[Indexed for MEDLINE]
Free PMC Article

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