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Cell Stem Cell. 2011 Oct 4;9(4):285-6. doi: 10.1016/j.stem.2011.09.004.

eNERgizing pluripotent gene transcription.

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1
The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, USA.

Abstract

Nucleotide excision repair proteins are classically associated with DNA repair. However, a study by Fong et al. (2011) in the most recent issue of Cell demonstrates that the XPC/RAD23B/CETN2 nucleotide excision repair complex additionally functions as a transcriptional coactivator of Oct4/Sox2, critically regulating maintenance and reestablishment of stem cell pluripotency.

PMID:
21982224
DOI:
10.1016/j.stem.2011.09.004
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