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Mol Cell. 2011 Oct 7;44(1):3-4. doi: 10.1016/j.molcel.2011.09.006.

Revoking the cellular license to replicate: yet another AAA assignment.

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Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.


In this issue of Molecular Cell, Raman et al. (2011) and Franz et al. (2011) establish the AAA ATPase CDC-48/p97 as an essential regulator of eukaryotic DNA replication that coordinates the release of chromatin-bound CDT1 with its degradation by the proteasome.

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