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J Am Chem Soc. 2011 Dec 14;133(49):19582-5. doi: 10.1021/ja206998x. Epub 2011 Nov 18.

Bioresponsive mesoporous silica nanoparticles for triggered drug release.

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1
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute Technology, Cambridge, Massachusetts 02139, USA.

Abstract

Mesoporous silica nanoparticles (MSNPs) have garnered a great deal of attention as potential carriers for therapeutic payloads. However, achieving triggered drug release from MSNPs in vivo has been challenging. Here, we describe the synthesis of stimulus-responsive polymer-coated MSNPs and the loading of therapeutics into both the core and shell domains. We characterize MSNP drug-eluting properties in vitro and demonstrate that the polymer-coated MSNPs release doxorubicin in response to proteases present at a tumor site in vivo, resulting in cellular apoptosis. These results demonstrate the utility of polymer-coated nanoparticles in specifically delivering an antitumor payload.

PMID:
21981330
PMCID:
PMC3295203
DOI:
10.1021/ja206998x
[Indexed for MEDLINE]
Free PMC Article
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