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Genes Brain Behav. 2012 Mar;11(2):127-36. doi: 10.1111/j.1601-183X.2011.00738.x. Epub 2011 Dec 5.

BDNF Val66Met and cognition: all, none, or some? A meta-analysis of the genetic association.

Author information

1
Human Development, Teachers College, Columbia University, New York, NY, USA.

Abstract

The Val66Met, G196A (rs6265) polymorphism in the brain-derived neurotrophic factor gene, BDNF, located at 11p13, has been associated with a wide range of cognitive functions. Yet, the pattern of results is complex and conflicting. In this study, we conducted a meta-analysis that included 23 publications containing 31 independent samples comprised of 7095 individuals. The phenotypes that were examined in this analysis covered a wide variety of cognitive functions and included indicators of general cognitive ability, memory, executive function, visual processing skills and cognitive fluency. The meta-analysis did not establish significant genetic associations between the Val66Met polymorphism and any of the phenotypes that were included.

PMID:
21980924
PMCID:
PMC3268899
DOI:
10.1111/j.1601-183X.2011.00738.x
[Indexed for MEDLINE]
Free PMC Article

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