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PLoS One. 2011;6(9):e25508. doi: 10.1371/journal.pone.0025508. Epub 2011 Sep 28.

Kv7 channels can function without constitutive calmodulin tethering.

Author information

1
Unidad de Biofísica, Consejo Superior de Investigaciones Científicas-Universidad del País Vasco/Euskal Herriko Unibersitatea, Leioa, Spain.

Abstract

M-channels are voltage-gated potassium channels composed of Kv7.2-7.5 subunits that serve as important regulators of neuronal excitability. Calmodulin binding is required for Kv7 channel function and mutations in Kv7.2 that disrupt calmodulin binding cause Benign Familial Neonatal Convulsions (BFNC), a dominantly inherited human epilepsy. On the basis that Kv7.2 mutants deficient in calmodulin binding are not functional, calmodulin has been defined as an auxiliary subunit of Kv7 channels. However, we have identified a presumably phosphomimetic mutation S511D that permits calmodulin-independent function. Thus, our data reveal that constitutive tethering of calmodulin is not required for Kv7 channel function.

PMID:
21980481
PMCID:
PMC3182250
DOI:
10.1371/journal.pone.0025508
[Indexed for MEDLINE]
Free PMC Article

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