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Z Rheumatol. 2011 Oct;70(8):698-700. doi: 10.1007/s00393-011-0780-z.

[T-cells in ANCA-associated vasculitis].

[Article in German]

Author information

1
Poliklinik für Rheumatologie, Vaskulitiszentrum UKSH & Klinikum Bad Bramstedt, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland. peter.lamprecht@uk-sh.de

Abstract

CD4+NKG2D+effector memory T-cell-mediated endothelial cell damage and a Th17 dominated cytokine profile of PR3-specific T-cells may play an important role in the pathogenesis of granulomatosis with polyangiitis (Wegener's). The anti-IL-5 antibody mepolizumab (anti-IL-5) induces remission in Churg-Strauss syndrome.

PMID:
21979321
DOI:
10.1007/s00393-011-0780-z
[Indexed for MEDLINE]
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