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J Cardiovasc Pharmacol. 2011 Oct;58(4):339-44. doi: 10.1097/FJC.0b013e31821bc3f0.

A kinase-anchoring proteins and adenylyl cyclase in cardiovascular physiology and pathology.

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1
Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030, USA.

Abstract

3'-5'-Cyclic adenosine monophosphate (cAMP), generated by adenylyl cyclase (AC), serves as a second messenger in signaling pathways regulating many aspects of cardiac physiology, including contraction rate and action potential duration, and in the pathophysiology of hypertrophy and heart failure. A kinase-anchoring proteins localize the effect of cAMP in space and time by organizing receptors, AC, protein kinase A, and other components of the cAMP cascade into multiprotein complexes. In this review, we discuss how the interaction of A kinase-anchoring proteins with distinct AC isoforms affects cardiovascular physiology.

PMID:
21978991
PMCID:
PMC3191934
DOI:
10.1097/FJC.0b013e31821bc3f0
[Indexed for MEDLINE]
Free PMC Article
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