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Drug Discov Today. 2012 Feb;17(3-4):153-9. doi: 10.1016/j.drudis.2011.09.014. Epub 2011 Sep 29.

The formulation of polyhedral boranes for the boron neutron capture therapy of cancer.

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  • 1School of Pharmacy and Chemistry, Kingston University, Kingston-upon Thames KT1 2EE, UK.


The early promise of boron neutron capture therapy as a method for the treatment of cancer has been inhibited by the inherent toxicity associated with therapeutically useful doses of ¹⁰B-containing pharmacophores, the need for target-tissue specificity and the challenges imposed by biological barriers. Although developments in the synthetic chemistry of polyhedral boranes have addressed issues of toxicity to a considerable extent, the optimisation of the transport and the delivery of boronated agents to the site of action--the subject of this review--is a challenge that is addressed by the development of innovative formulation strategies.

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