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Biochim Biophys Acta. 2012 Jan;1819(1):28-37. doi: 10.1016/j.bbagrm.2011.09.004. Epub 2011 Sep 29.

FOXM1: From cancer initiation to progression and treatment.

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1
Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK.

Abstract

The Forkhead box protein M1 (FOXM1) transcription factor is a regulator of myriad biological processes, including cell proliferation, cell cycle progression, cell differentiation, DNA damage repair, tissue homeostasis, angiogenesis and apoptosis. Elevated FOXM1 expression is found in cancers of the liver, prostate, brain, breast, lung, colon, pancreas, skin, cervix, ovary, mouth, blood and nervous system, suggesting it has an integral role in tumorigenesis. Recent research findings also place FOXM1 at the centre of cancer progression and drug sensitivity. In this review the involvement of FOXM1 in various aspects of cancer, in particular its role and regulation within the context of cancer initiation, progression, and cancer drug response, will be summarised and discussed.

PMID:
21978825
DOI:
10.1016/j.bbagrm.2011.09.004
[Indexed for MEDLINE]
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