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J Pregnancy. 2011;2011:368067. doi: 10.1155/2011/368067. Epub 2011 Oct 1.

Recurrence of congenital heart disease in cases with familial risk screened prenatally by echocardiography.

Author information

1
Department of Pediatric Cardiosurgery, Center of Fetal Cardiology, Policlinico San Donato IRCCS, Via Morandi 30, San Donato Milanese, 20097 Milan, Italy. cardiologiafetale.psd@grupposandonato.it

Abstract

OBJECTIVES:

To evaluate the recurrence of congenital heart disease (CHD) in pregnant women with familial risk who had been referred for fetal echocardiography.

MATERIAL AND METHODS:

1634 pregnancies from 1483 women with familial history of CHD in one or more relatives were studied. Fetal cardiologic diagnosis was compared with postnatal findings at 6 months or at autopsy.

RESULTS:

Total recurrence rate of CHD was 3.98%, 4.06% in single familial risk, 2.9% in double, and 5% in multiple risk. It was 3.5% in case of one previously affected child; 4.5% with 2 children; 5.2% with the mother alone affected and 7,5% with father alone affected and 3.5% with a single distant relative. Exact concordance of CHD was found in 21.5% and a partial concordance in 20% of cases.

CONCLUSIONS:

Our data show a higher recurrence rate of CHD than previously published data and high relative risk ratios compared to normal population.

PMID:
21977323
PMCID:
PMC3184425
DOI:
10.1155/2011/368067
[Indexed for MEDLINE]
Free PMC Article
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