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Maedica (Buchar). 2011 Jan;6(1):52-8.

Generic Substitution Issues: Brand-generic Substitution, Generic-generic Substitution, and Generic Substitution of Narrow Therapeutic Index (NTI)/Critical Dose Drugs.

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1
"Titu Maiorescu" University, Bucharest, Romania.

Abstract

Doctors accuse individual variability or lack of quality of generic drugs for adverse reactions or lack of efficacy. The variability of effect of generic substitution, although accepted by clinicians as possible, is little discussed or even understood by them. The situation is really serious in the case of generic substitution of drugs with narrow therapeutic index (NTI) or critical dose. In this paper we review the basic notions of variability and effectiveness of generic medication and change of attitude that would improve the use of these drugs.

KEYWORDS:

Generic Drugs; Generic-generic substitution; brand-generic substitution; narrow terapeutic index

PMID:
21977191
PMCID:
PMC3150029
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