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Int J Nanomedicine. 2011;6:2053-61. doi: 10.2147/IJN.S24344. Epub 2011 Sep 20.

Effects of a novel pH-sensitive liposome with cleavable esterase-catalyzed and pH-responsive double smart mPEG lipid derivative on ABC phenomenon.

Author information

1
School of Pharmacy, Yantai University, Yantai.

Abstract

BACKGROUND:

The ABC phenomenon is described as a syndrome of accelerated clearance of polyethylene glycol (PEG)-modified liposomes from the bloodstream when repeatedly injected, with their increased accumulation in the liver and spleen.

METHODS:

To clarify this immune response phenomenon, we evaluated a novel modified pH-sensitive liposome with a cleavable double smart PEG-lipid derivative (mPEG-Hz-CHEMS).

RESULTS:

The ABC phenomenon in mice was brought about by repeated injection of conventional PEG-PE liposomes and was accompanied by a greatly increased uptake in the liver. However, a slight ABC phenomenon was brought about by repeated injection of mPEG-CHEMS liposomes and was accompanied by only a slightly increased uptake in the liver, and repeated injection of mPEG-Hz-CHEMS liposomes did not induce the ABC phenomenon and there was no increase in liver accumulation. This finding indicates that the cleavable mPEG-Hz-CHEMS derivative could lessen or eliminate the ABC phenomenon induced by repeated injection of PEGylated liposomes.

CONCLUSION:

This research has shed some light on a solution to the ABC phenomenon using a cleavable PEG-Hz-CHEMS derivative encapsulated in nanoparticles.

KEYWORDS:

accelerated blood clearance; cleavable; double smart; mPEG-lipid derivates; pH-sensitive liposome

PMID:
21976980
PMCID:
PMC3181064
DOI:
10.2147/IJN.S24344
[Indexed for MEDLINE]
Free PMC Article

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