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Toxicol Int. 2011 Jul;18(2):87-93. doi: 10.4103/0971-6580.84258.

Mechanisms pertaining to arsenic toxicity.

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1
Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar - 143 005.

Abstract

Arsenic is an environmental pollutant and its contamination in the drinking water is considered as a serious worldwide environmental health threat. The chronic arsenic exposure is a cause of immense health distress as it accounts for the increased risk of various disorders such as cardiovascular abnormalities, diabetes mellitus, neurotoxicity, and nephrotoxicity. In addition, the exposure to arsenic has been suggested to affect the liver function and to induce hepatotoxicity. Moreover, few studies demonstrated the induction of carcinogenicity especially cancer of the skin, bladder, and lungs after the chronic exposure to arsenic. The present review addresses diverse mechanisms involved in the pathogenesis of arsenic-induced toxicity and end-organ damage.

KEYWORDS:

Arsenic; carcinogenicity; cardiovascular dysfunction; diabetes; hepatotoxicity; nephrotoxicity; neurotoxicity

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