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Intensive Care Med. 2011 Dec;37(12):1976-85. doi: 10.1007/s00134-011-2368-0. Epub 2011 Oct 6.

New insights into weaning from mechanical ventilation: left ventricular diastolic dysfunction is a key player.

Author information

1
Department of Critical Care, School of Medicine, University of Thessaly, University Hospital of Larissa, Thessaly, Greece. y_papanikolaou@hotmail.com.
2
Biopolis, 41110, Larissa, Greece. y_papanikolaou@hotmail.com.
3
Department of Critical Care, School of Medicine, University of Thessaly, University Hospital of Larissa, Thessaly, Greece.
4
2nd Department of Anaesthesiology, School of Medicine, University of Athens, University Hospital of Athens 'Attikon', Athens, Greece.
5
Department of Critical Care, General State Hospital of Athens, Athens, Greece.
6
Department of Biomathematics, School of Medicine, University of Thessaly, Larissa, Greece.
7
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA.
8
Department of Critical Care, School of Medicine, University of Thessaly, University Hospital of Larissa, Thessaly, Greece. ezakynth@yahoo.com.
9
Biopolis, 41110, Larissa, Greece. ezakynth@yahoo.com.

Abstract

PURPOSE:

To investigate the diagnostic performance of Doppler echocardiography (DE) in predicting the outcome of weaning from mechanical ventilation in patients without overt cardiac disease.

METHODS:

Fifty critical care noncardiac patients who fulfilled predetermined criteria for weaning underwent DE before and at the end of spontaneous breathing trial (pre-SBT/end-SBT, respectively). "Conventional" mitral inflow analysis and "advanced" DE parameters [tissue Doppler imaging (TDI)-derived mitral/tricuspid annular velocities and color M-mode Doppler velocity of propagation (V p)] were used to assess left ventricular (LV) diastolic function/filling pressures. Weaning was considered successful if patients had been extubated after successful SBT and sustained spontaneous breathing for more than 48 h.

RESULTS:

Twenty-eight patients (56%) failed weaning: 23 patients failed SBT and 5 required reintubation within 48 h. Weaning failure was associated with the degree of LV diastolic dysfunction at pre-SBT (P = 0.01). Patients who failed weaning presented evidence of increased LV filling pressures at pre-SBT, by demonstrating increased E/E m and E/V p ratios compared with patients with successful outcome (P ≤ 0.004); pre-SBT values of lateral E/E m greater than 7.8 and E/V p greater than 1.51 predicted weaning failure with an area under the curve, sensitivity (%), and specificity (%) of 0.86, 79, and 100, and 0.74, 75, and 73, respectively. Lateral E/E m was the only factor independently associated with weaning failure before SBT; OR (95% CI) 5.62 (1.17-26.96), P = 0.03.

CONCLUSIONS:

Our findings suggest that LV diastolic dysfunction is significantly associated with weaning outcome in critically ill patients with preserved LV systolic function. An E/E m ratio greater than 7.8 may identify patients at high risk of weaning failure.

KEYWORDS:

Doppler echocardiography; Left ventricular diastolic dysfunction; Spontaneous breathing trial; Weaning outcome

PMID:
21976188
DOI:
10.1007/s00134-011-2368-0
[Indexed for MEDLINE]

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