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J Cell Biochem. 2012 Feb;113(2):426-32. doi: 10.1002/jcb.23393.

Ion transporting proteins of human bronchial epithelium.

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Department of Biophysics, Warsaw University of Life Sciences (SGGW), 159 Nowoursynowska St, 0-776 Warsaw, Poland.


The electrolyte transport system across human airway epithelium followed by water movement is essential for the normal mucociliary clearance that allows the maintenance of the aseptic condition of the respiratory tract. The function of epithelial cells is to control and regulate ionic composition and volume of fluids in the airways. Various types of proteins taking part in assuring effective ions and water transport in apical and basolateral membranes of the airway epithelium have been found (e.g., CFTR, ENaC, CaCC, ORCC, potassium channels, NaKATPase, aquaporins). The paper reviews the current state of the art in the field of ion channels, transporters, and other signaling proteins identified in the human bronchial epithelium.

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