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J Cardiovasc Pharmacol. 2011 Oct;58(4):446-9. doi: 10.1097/FJC.0B013E31822D93CB.

Increases in blood pressure and heart rate induced by caffeine are inhibited by (-)-epigallocatechin-3-O-gallate: involvement of catecholamines.

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Research Institute of Veterinary Medicine, College of Pharmacy and Medical Research Center (CICT), Chungbuk National University, Cheongju, Republic of Korea.


In a previous experiment, (-)-epigallocatechin-3-O-gallate (EGCG) reduced caffeine-induced locomotor activity and stereotyped behaviors and inhibited caffeine-induced neuronal stimulant activity. This research was performed to give additional evidence that EGCG counteracts caffeine-induced stimulant effects in animals. EGCG inhibited caffeine-induced cardiovascular activation measures, such as arterial pressure and heart rate. In addition, the increases in the levels of adrenaline and noradrenaline in the blood induced by caffeine was reduced by EGCG. We suggest that EGCG may reduce caffeine-induced increases in blood pressure and heart rate and may decrease the levels of catecholamines in the blood. Therefore, EGCG counteracts caffeine-induced cardiovascular activity. The stimulant effects of caffeine should be reduced by the amount of EGCG in green tea.

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