Format

Send to

Choose Destination
Am Rev Respir Dis. 1979 Feb;119(2):287-91.

Growth of herpes simplex and cytomegalovirus in cultured human alveolar macrophages.

Abstract

In laboratory animals, macrophages play a central role in controlling certain viral infections. Because the adult human lung is more susceptible to infection with cytomegalovirus than herpes simplex virus, we compared the replication of these two viruses in vitro in human alveolar macrophages. The growth of herpes simplex virus in alveolar macrophages was extremely limited, peak titers being only 1.8-fold greater than adsorbed virus titers. Cytomegalovirus, on the other hand, replicated in normal adult alveolar macrophages to the same extent as in permissive tissue culture cell. These data suggest that the human alveolar macrophage may play a central role in the control of lung infection with herpes simplex virus.

PMID:
219737
DOI:
10.1164/arrd.1979.119.2.287
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center