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Ocul Immunol Inflamm. 2011 Oct;19(5):382-3. doi: 10.3109/09273948.2011.606593.

Efficacy of tocilizumab in two patients with anti-TNF-alpha refractory uveitis.

Author information

1
Ophthalmology Department, University Hospital, Dijon, France.

Abstract

PURPOSE:

To report on two patients with refractory uveitis treated with tocilizumab; a new humanized monoclonal antibody against the interleukin-6 receptor (IL-6R).

DESIGN:

Retrospective interventional case series.

METHODS:

Both patients received a monthly infusion of tocilizumab 8 mg/kg; associated with corticosteroids. Outcome measures were visual acuity and central retinal thickness evaluated with optical coherence tomography.

RESULTS:

An improvement in visual acuity and a decrease in macular edema were observed in these two patients.

CONCLUSIONS:

Tocilizumab seems to be a promising treatment in refractory uveitis. A prospective study is needed to evaluate the role of this new agent in the management of refractory uveitis.

PMID:
21970668
DOI:
10.3109/09273948.2011.606593
[Indexed for MEDLINE]

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