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Adm Policy Ment Health. 2013 Mar;40(2):76-86. doi: 10.1007/s10488-011-0376-6.

Development and validation of the Individual Burden of Illness Index for Major Depressive Disorder (IBI-D).

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1
Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center and David Geffen School of Medicine at UCLA, 8730 Alden Drive, Los Angeles, CA 90048, USA. Waguih.Ishak@cshs.org

Abstract

This study aims at developing a single numerical measure that represents a depressed patient's individual burden of illness. An exploratory study examined depressed outpatients (n = 317) followed by a hypothesis confirmatory study using the NIMH STAR*D trial (n = 2,967). Eigenvalues/eigenvectors were obtained from the Principal Component Analyses of patient-reported measures of symptom severity, functioning, and quality of life. The study shows that a single principal component labeled as the Individual Burden of Illness Index for Depression (IBI-D) accounts for the vast majority of the variance contained in these three measures providing a numerical z score for clinicians and investigators to determine an individual's burden of illness, relative to other depressed patients.

PMID:
21969214
PMCID:
PMC5154958
DOI:
10.1007/s10488-011-0376-6
[Indexed for MEDLINE]
Free PMC Article
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