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Nat Rev Genet. 2011 Oct 4;12(11):793-801. doi: 10.1038/nrg3050.

The early bird catches the worm: new technologies for the Caenorhabditis elegans toolkit.

Author information

1
Cancer Biology Program and Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA.

Abstract

The inherent simplicity of Caenorhabditis elegans and its extensive genetic toolkit make it ideal for studying complex biological processes. Recent developments further increase the usefulness of the worm, including new methods for: altering gene expression, altering physiology using optogenetics, manipulating large numbers of worms, automating laborious processes and processing high-resolution images. These developments both enhance the worm as a model for studying processes such as development and ageing and make it an attractive model in areas such as neurobiology and behaviour.

PMID:
21969037
PMCID:
PMC4719766
DOI:
10.1038/nrg3050
[Indexed for MEDLINE]
Free PMC Article

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