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Nat Cell Biol. 2011 Oct 3;13(10):1183-5. doi: 10.1038/ncb2352.

Spindle positioning: going against the actin flow.

Author information

1
Coll├Ęge de France, Center for Interdisciplinary Research in Biology, UMR-CNRS7241/INSERM-U1050, 11 place Marcelin Berthelot, 75005 Paris, France. marie-helene.verlhac@college-de-france.fr

Abstract

Successful completion of meiosis in vertebrate oocytes requires the localization and maintenance of the meiotic spindle at the cell cortex. Arp2/3-nucleated actin filaments are now shown to flow away from the cortex overlying the spindle, resulting in cytoplasmic streaming, which maintains the spindle in its asymmetric position.

PMID:
21968992
DOI:
10.1038/ncb2352
[Indexed for MEDLINE]

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