Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell Mol Life Sci. 2011 Nov;68(22):3675-85. doi: 10.1007/s00018-011-0830-3. Epub 2011 Oct 4.

The potter's wheel: the host's role in sculpting its microbiota.

Author information

1
Department of Microbiology and Immunology, University of California Davis School of Medicine, Davis, CA 95616, USA.

Abstract

Animals, ranging from basal metazoans to primates, are host to complex microbial ecosystems; engaged in a symbiotic relationship that is essential for host physiology and homeostasis. Epithelial surfaces vary in the composition of colonizing microbiota as one compares anatomic sites, developmental stages and species origin. Alterations of microbial composition likely contribute to susceptibility to several distinct diseases. The forces that shape the colonizing microbial composition are the focus of much current investigation, and it is evident that there are pressures exerted both by the host and the external environment to mold these ecosystems. The focus of this review is to discuss recent studies that demonstrate the critical importance of host factors in selecting for its microbiome. Greater insight into host-microbiome interactions will be essential for understanding homeostasis at mucosal surfaces, and developing useful interventions when homeostasis is disrupted.

PMID:
21968920
PMCID:
PMC3222938
DOI:
10.1007/s00018-011-0830-3
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Support Center