Format

Send to

Choose Destination
See comment in PubMed Commons below
J Nutr Health Aging. 2011 Aug;15(8):690-4.

Physical frailty predicts future cognitive decline - a four-year prospective study in 2737 cognitively normal older adults.

Author information

1
S.H. Ho Centre for Gerontology and Geriatric, The Chinese University of Hong Kong and Pok Oi Hospital, Hong Kong, China. auyeungtw@cuhk.edu.hk

Abstract

OBJECTIVE:

To examine the association between baseline frailty measurements and cognitive function 4 years later.

DESIGN:

Prospective observational study.

SETTING:

Community.

PARTICIPANTS:

Two thousand seven hundred and thirty seven cognitively normal older adults.

MEASUREMENT:

The appendicular muscle mass (ASM), hand grip strength, timed chair-stand test, walking speed and step length were measured at baseline. The Mini-mental state examination (MMSE) was administered at baseline and 4 years later.

RESULTS:

In men, all baseline frailty measurements, namely, being underweight, lower ASM, weaker grip strength, slower chair-stand test, shorter step length, slower timed walk were significantly associated with a lower MMSE score 4 years afterwards. After adjustment for age, years of education and baseline MMSE score, ASM and timed walk became insignificant. In women, all frailty measurements except underweight and low ASM were significantly associated with MMSE score 4 years later. Moreover, only weaker grip strength persisted to be significant after adjustment for age, years of education and baseline MMSE score.

CONCLUSION:

Physical frailty, as represented by being underweight, weaker grip strength, slower chair-stand test, shorter step-length in men and weaker grip strength in women, was associated with cognitive decline over a four year period.

PMID:
21968866
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center