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Epilepsia. 2011 Oct;52 Suppl 8:28-30. doi: 10.1111/j.1528-1167.2011.03230.x.

Febrile infection-related epilepsy syndrome (FIRES): does duration of anesthesia affect outcome?

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Pediatric Epilepsy Unit, Tel Aviv Sourasky Medical Center, Tel Aviv University, 6 Weitzman Street, Tel Aviv, Israel.


We conducted a retrospective multicenter study on children who had been included in eight studies published between November 2001 and July 2010 to explore the correlations between burst-suppression coma (BSC) with outcome in febrile infection-related epilepsy syndrome (FIRES). The 77 enrolled patients presented with prolonged refractory status epilepticus. BSC was induced in 46 patients. Cognitive levels at follow-up were significantly associated with duration of a BSC (p=0.005). The outcome of FIRES is poor. Treatment by inducing a prolonged BSC was associated with a worse cognitive outcome.

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