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Epilepsia. 2011 Oct;52 Suppl 8:19-20. doi: 10.1111/j.1528-1167.2011.03227.x.

Blood-brain barrier dysfunction, status epilepticus, seizures, and epilepsy: a puzzle of a chicken and egg?

Author information

1
Ben-Gurion University of the Negev, Beer-Sheva, Israel. alonf@exchange.bgu.ac.il

Abstract

Status epilepticus is often associated with endothelial dysfunction and increased vessels permeability. We discuss here the direct role of blood-brain barrier (BBB) dysfunction in epileptogenesis and brain damage. On the cellular level, astrocytes respond early to the efflux of serum proteins in the presence of dysfunctional BBB, with activation of the innate immune system and disturbed homeostasis of extracellular potassium and glutamate. In turn, there is enhanced excitability of neurons and altered network connectivity. Transforming growth factor beta (TGF-β) signaling appears to be a potential new target for the prevention of epileptogenesis and secondary damage following status epilepticus.

PMID:
21967353
PMCID:
PMC3234990
DOI:
10.1111/j.1528-1167.2011.03227.x
[Indexed for MEDLINE]
Free PMC Article

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