Format

Send to

Choose Destination
J Antimicrob Chemother. 2012 Jan;67(1):154-8. doi: 10.1093/jac/dkr399. Epub 2011 Sep 29.

Automated quantitative drug susceptibility testing of non-tuberculous mycobacteria using MGIT 960/EpiCenter TB eXiST.

Author information

1
Institut für Medizinische Mikrobiologie, Universität Zürich, Nationales Zentrum für Mykobakterien, Zürich, Switzerland.

Abstract

OBJECTIVES:

To assess the predictive value of in vitro drug susceptibility testing (DST) in slow-growing non-tuberculous mycobacteria (NTM), knowledge on quantitative levels of drug susceptibility should be available. The aim of this study was to investigate the suitability of the MGIT 960/TB eXiST system for quantitative DST of NTM.

METHODS:

We have assessed quantitative levels of drug susceptibility for clinical isolates of Mycobacterium avium, Mycobacterium intracellulare and Mycobacterium kansasii by comparing radiometric Bactec 460TB-based DST with non-radiometric DST using MGIT 960/TB eXiST.

RESULTS:

MGIT 960/TB eXiST gives results comparable to those of Bactec 460TB.

CONCLUSIONS:

The MGIT 960/TB eXiST appears suitable for quantitative DST of NTM.

PMID:
21965431
DOI:
10.1093/jac/dkr399
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for Zurich Open Access Repository and Archive
Loading ...
Support Center