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Carcinogenesis. 2011 Dec;32(12):1862-6. doi: 10.1093/carcin/bgr214. Epub 2011 Sep 30.

Breast cancer susceptibility polymorphisms and endometrial cancer risk: a Collaborative Endometrial Cancer Study.

Collaborators (168)

Webb P, Young J, McQuire L, Baron-Hay S, Bell D, Bonaventura A, Brand A, Braye S, Carter J, Chan F, Dalrymple C, Ferrier A, Gard G, Hacker N, Hogg R, Houghton R, Marsden D, McIlroy K, Otton G, Pather S, Proietto A, Robertson G, Scurry J, Sharma R, Wain G, Wong F, Armes J, Crandon A, Cummings M, Land R, Nicklin J, Perrin L, Obermair A, Ward B, Davy M, Dodd T, Miller J, Oehler M, Paramasivum S, Pierides J, Whitehead F, Blomfield P, Challis D, Neesham D, Pyman J, Quinn M, Rome R, Weitzer M, Brennan B, Hammond I, Leung Y, McCartney A, Stewart C, Thompson J, O'Brien S, Moore S, Ferguson K, Walsh M, Cicero R, Green L, Griffith J, Jackman L, Ranieri B, O'Brien M, Schultz P, Alexander B, Baxter C, Croy H, Fitzgerald A, Herron E, Hill C, Jones M, Maidens J, Marshall A, Martin K, Mayhew J, Minehan E, Roffe D, Shirley H, Steane H, Stenlake A, Ward A, Webb S, White J, Despierre E, Van Brussel T, Peuteman G, Tomlinson I, Adams M, Al-Samarraie A, Anwar S, Athavale R, Awad S, Bali A, Barnes A, Cawdell G, Chan S, Chin K, Cornes P, Crawford M, Cullimore J, Ghaem-Maghami S, Gornall R, Green J, Hall M, Harvey M, Hawe J, Head A, Herod J, Hingorani M, Hocking M, Holland C, Hollingsworth T, Hollingworth J, Ind T, Irvine R, Irwin C, Katesmark M, Kehoe S, Kheng-Chew G, Lankester K, Linder A, Luesley D, Lynch CB, McFarlane V, Naik R, Nicholas N, Nugent D, Oates S, Oladipo A, Papadopoulos A, Pearson S, Radstone D, Raju S, Rathmell A, Redman C, Rymer M, Sarhanis P, Sparrow G, Stuart N, Sundar S, Thompson A, Tinkler S, Trent S, Tristram A, Walji N, Woolas R, Szeszenia-Dabrowska N, Zatonski W, Chao P, Stagner M, Baynes C, Luccarini C, Conroy D, Harrington P, Mayes R, Munday H, Schinnar R, Weber AL, Bunin G, Berlin JA, Baumgarten M, DeMichele A, Rubin SC, Berlin M, Troxel AB, Turzo E, Burgh D.

Author information

1
Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.

Abstract

Recent large--scale association studies, both of genome-wide and candidate gene design, have revealed several single-nucleotide polymorphisms (SNPs) which are significantly associated with risk of developing breast cancer. As both breast and endometrial cancers are considered to be hormonally driven and share multiple risk factors, we investigated whether breast cancer risk alleles are also associated with endometrial cancer risk. We genotyped nine breast cancer risk SNPs in up to 4188 endometrial cases and 11,928 controls, from between three and seven Caucasian populations. None of the tested SNPs showed significant evidence of association with risk of endometrial cancer.

PMID:
21965274
PMCID:
PMC3220608
DOI:
10.1093/carcin/bgr214
[Indexed for MEDLINE]
Free PMC Article

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